I've often wondered how certain games would play out if they included things like modern day police forces, weaponry, etc. I mean, how difficult would Ganon really be if you had an AK at your disposal? The Blight in Dragon Age: Origins would be nothing if you had an RPG to wipe out their swarms on the battlefield. Diablo III would be a bit of cinch of you had a SWAT team backing you up.
Of course this logic doesn't apply to most games outside of the fantasy realm. THE LAST OF US WITH GUNS! ...oh. RESIDENT EVIL WITH A POLICE TEAM! ...oh. BIOSHOCK INFINITE WITH GRENADES! ...oh.